Randolph Bell, Chief of Surgery at Chastain Park Memorial Hospital, performs an appendectomy on a patient when an accident involving a tremor in his left hand leads to a severed artery. The patient bleeds out and the incident is covered up by the surgical team. Due to Randolph's high complication rate, his nickname is "HODAD"—Hands of Death and Destruction. Devon Pravesh reports for his first day as a resident intern; he is assigned to third-year resident Conrad Hawkins, who seems "impossible" to work with. Conrad and nurse practitioner Nic Nevin share a private moment in an on-call room, hinting at a romantic relationship. Lily Kendall, a recurrent leukemia patient who is beloved by the hospital staff, is admitted for an infection. A combative woman with endocarditis enters the ER and loses consciousness, giving Devon a chance to run his first code. During a live stream of a surgery in which Randolph operates using the Titian—an advanced robotic surgical tool—Conrad discovers that surgical resident Mina Okafor is actually performing the procedure, unbeknownst to the audience.